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KMID : 0352720110350030375
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Journal of Ginseng Research
2011 Volume.35 No. 3 p.375 ~ p.383
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Effects of Minor Ginsenosides, Ginsenoside Metabolites, and Ginsenoside Epimers on the Growth of Caenorhabditis elegans
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Lee Joon-Hee
Ahn Ji-Yun
Shin Tae-Joon
Choi Sun-Hye
Lee Byung-Hwan
Hwang Sung-Hee
Kang Ji-Yeon
Kim Hyeon-Joong
Park Chan-Woo
Nah Seung-Yeol
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Abstract
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In the previous report, we have demonstrated that ginsenoside Rc, one of major ginsenosides, is a major component for the restoration for normal growth of worms in cholesterol-deprived medium. In the present study, we further investigated the roles of minor ginsenosides, such as ginsenoside Rh1 and Rh2, ginsenoside metabolites such as compound K (CK), protopanaxadiol (PPD), and protopanaxatriol (PPT) and ginsenoside epimers such as 20(R)- and 20(S)-ginsenoside Rg_3 in cholesterol-deprived medium. We found that ginsenoside Rh_1 almost restored normal growth of worms in cholesterol-deprived medium in F1 generation. However, supplement of ginsenoside Rh_2 caused a suppression of worm growths in cholesterol-deprived medium. In addition, CK and PPD also slightly restored normal growth of worms in cholesterol-deprived medium but PPT not. In experiments using ginsenoside epimers, supplement of 20(S)- but not 20(R)-ginsenoside Rg3 in cholesterol-deprived medium also almost restored worm growth. These results indicate that the absence or presence of carbohydrate component at backbone of ginsenoside, the number of carbohydrate attached at carbon-3, and the position of hydroxyl group at carbon-20 of ginsenoside might plays important roles in restoration of worm growth in cholesterol-deprived medium.
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KEYWORD
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Panax ginseng, Caenorhabditis elegans, Ginsenoside metabolites, Ginsenoside epimers, Growth
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